By J. W. Hopewell, W. Calvo, R. Jaenke, H. S. Reinhold, M. E. C. Robbins, E. M. Whitehouse (auth.), PD Dr. Wolfgang Hinkelbein, Dr. Gregor Bruggmoser, Prof. Dr. Hermann Frommhold, Prof. Dr. Michael Wannenmacher (eds.)

Biologists and radiotherapists current their experimental paintings and scientific info within the box of radiation accidents of standard tissues and organs. specific regard is payed to the relevance of organic mechanisms in medical occasions. ideas of radiation harm and mixed therapy toxicity in radio-chemotherapy are being defined. the most issues mentioned are the significance of microvasculature, time, doseand fractionation and elements editing medical radioresponse for early andlate radiation results. Tissues and organs thought of during this quantity are mucosa and dermis, lung and middle, bladder and muscle, CNS and eye. certain difficulties of pediatric radiotherapy, TBI, IORT and moment malignacies also are mentioned.

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Additional info for Acute and Long-Term Side-Effects of Radiotherapy: Biological Basis and Clinical Relevance

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Therefore, in contrast to increased acute normal tissue damage caused by noxious factors which preferentially reduce the tumor control probability for affected patients, increased late normal tissue damage caused by confounding factors may, via tolerance doses, reduce the chance of local tumor control for all patients undergoing radiotherapy.

2 \ 0 1 \ 2 3 Dose (Gy) 4 5 Fig. 5. Typical experiment using V79 hamster cells in vitro irradiated with single doses of X-rays or neutrons. 6Gy, the dose-survival relationship conforms to a conventional LQ model. 6Gy, the LQ model substantially underpredicts the effect of X-rays. The response to neutrons is described by a simple exponential survival curve and there is no indication of increased sensitivity to low-dose neutrons. 2Gy, the response to X-rays and neutrons is similar this level of survival.

5 Gy/min for kidney irradiation. 8 Gy/min. 3MeV (Folkard 1986). 7 Gy/min (1-10Gy). The dose rate was selected according to the dose delivered, so that exposure times were always greater than 35 s in order to maintain dosimetric accuracy. Normal Tissue Studies Acute skin reactions were scored during the period 10-32 days after irradiation, and an average value calculated (Denekamp 1973; Douglas and Fowler 1976; Joiner 1989). 5, which corresponds to transient moist desquamation at about day 20 postirradiation.

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