By John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. Michael I. Lethem (eds.)

Conceptually unsavoury, airway mucus is essential to homeostasis within the respiration tract. against this, whilst irregular, mucus contributes considerably to the pathophysiology of a couple of critical bronchial illnesses, together with bronchial asthma, continual bronchitis and cystic fibrosis. This quantity presents broad ranging and in-depth insurance of the medical and medical facets of airway mucus. It commences with introductory chapters which tackle the biochemical and molecular organic foundation of airway mucus and keeps with entire assurance of a few of the physiological and rheological elements of breathing secretions. The medical features of the subject are then thought of, with chapters discussing the involvement of mucus secretions in bacterial an infection and in hypersecretory ailments of the airway. the amount concludes with a dialogue of the healing facets of the subject, either by way of the prospective techniques to the therapy of mucus hypersecretion and the interplay of those medications with airway mucus. Written via best specialists within the box, each one contribution presents a entire assessment of its specific topic. Reflecting the newest advances during this vital quarter of breathing study, this quantity can be of serious curiosity to scientists and clinicians operating within the box of airway secretions and similar areas.

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Extra resources for Airway Mucus: Basic Mechanisms and Clinical Perspectives

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In addition to the large numbers ofO-linked oligosaccharide chains, it is becoming increasingly evident that small amounts of N-linked oligosaccharide are present in mucins. These appear to be of importance for the correct folding of the naked regions of the core protein essential for the initial stages of oligomerisation of the mucin monomers. Treatment of mucin-secreting cells or tissues in culture with tunicamycin abolishes oligomerisation [55]. The diversity of oligosaccharide structures on mucins reflects the expression of a large number of different glycosyltransferases in the secretory cells.

Biochem J 276: 667-675. 6. Sheehan JK, Richardson PS, Fung DCK, Howard M, Thornton DJ (1995) Analysis ofrespiratory mucus glycoproteins in asthma: A detailed study from a patient who died in status asthmaticus. Am J Respir Cell Mol Bioi 13: 748-756. 7. Davies JR, Hovenberg HW, Linden C-J, Howard R, Richardson PS, Sheehan JK, Carlstedt I (1996) Mucins in airway secretions from healthy and chronic bronchitic subjects. Biochem J313: 431-439. 8. Carlstedt I, Sheehan JK (1984) Macromolecular properties and polymeric structure of mucusglycoproteins.

Dohrman A, Tsuda T, Escudier E, Cardone M, Jany B, Gum J, Basbaum C (1994) Distribution oflysozyme and mucin (MUC2 and MUC3) mRNA in human bronchus. Exp Lung Res 20: 367-380. 39. Aubert Jp, Porchet N, Crepin M, Duterque-Coquillaud M, Vergnes G, Mazzuca M, Debuire B, Petiprez D, Degard P (1994) Evidence for different human tracheobronchial mucin peptides deduced from nucleotide cDNA sequences. Am J Respir Cell Mol Bioi 5: 178-185. 40. Audie JP, Janin A, Porchet N, Chopin MC, Gosselin B, Aubert JP (1993) Expression of human mucin genes in respiratory, digestive and reproductive tracts ascertained by in situ hybridization.

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