By Gerhard Freund (auth.), Milton M. Gross (eds.)

Dr. Milton M. Gross, the editor of those volumes, died on July 29, 1976, after a quick disorder. As chairman of the part on Biomedical examine in Alcoholism of the I.C.A.A., he had plan­ ned and taken to fruition the overseas "Symposium on Alcohol Intoxication and Withdrawal" which had taken position in Lausanne the month sooner than. He was once quite happy with the prestigious workforce of scientists he had helped to gather and was once eagerly trying to find­ ward to the booklet of those complaints which he was hoping might expand our figuring out of the phenomenology of alcoholism. Milton Gross used to be a most original guy within the quantity and diversity of his actions and accomplishments. He used to be a qualified psy­ chiatrist and psychoanalyst, a well-known scientific researcher, the writer of greater than fifty clinical papers, and the editor of 3 vital volumes on alcohol intoxication and withdrawal. He was once tremendous lively within the medical international of alcoholism as planner and coordinator of 3 overseas meetings, as chairman of the part on Biomedical examine of the I.C.A.A., and as a member of a W.H.O. job strength on Alcoholism. furthermore, he was once very lively in a number of clinical and repair committees in nationwide and native organizations.

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V. injection of an appropriate dose of ethanol during a 10-15 minute period. After 96 hours, ethanol infusion was discontinued and tremor sampling plus behavioral observations were taken each hour during the 34-hour withdrawal period. A. J. SKEEN 96 Hr 34Hr CONTROL 64 Hr 96 Hr 34 Hr RECOVERY ETHANOL INFU510NWITHDRAWAL 184 Hr RECOVERY EXPERIMENT AL SEQUENCE r r r r r r---l min--l 0 2 3 4 5 TREMOR SAMPLING PROCEDURE Figure 1. Experimental protocol for ethanol infusion and measurement of the withdrawal reaction.

Consequently, average tissue exposure per day over the 96-hour period was either 50, 100 or 200 mg/dl, respectively (see Fig. 2). The rate of increase in BEG (50 mg/dl) was held constant across conditions. A. J. , ethanol infusion was simply discontinued during the decreasing BEC phase of these schedules). Because of these rate constants, the cycle time was defined by the maximum BEC of the treatment. For example, the 100 mg/dl fluctuating schedule, as shown in Fig. 2, required 12 hrs per cycle: 4 hrs to read a maximum of 200 mg/dl at an infusion rate of 50 mg/dl and 8 hrs to return to approximately 0 mg/dl at a disappearance rate of 25 mg/dl.

10 31 30 73 93 Twitching Face & Ears Piloerection M. OKAMOTO ET AL. 36 100 50 ABNORM. U_c_H_ED. 1 Q v Z Figure 4. Top: Incidence of abnormal postures associated with withdrawal. Bottom: Temporal relationship of postural abnormalities. " These animals tended to remain immobile with partially flexed limbs but were able to move away from a noxious stimulus. The animals in the "crouched posture" were unable to stand; the limbs were held rigidly in flexion, and only half of these animals were able to crawl away following a noxious stimulation.

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