By Leonard T. Skeggs, Frederic E. Dorer, Joseph R. Kahn, Kenneth E. Lentz (auth.), Irvine H. Page M.D., F. Merlin Bumpus Ph.D. (eds.)

The historical past of arterial high blood pressure is either lengthy and brief; lengthy, considering brilliant (1827) first similar hardness of the heartbeat to hardness of the kidneys and hyper. trophy of the center; brief in that sleek learn started within the overdue twenties. so much of what we all know of those illnesses has been chanced on long ago fifty years. the trendy tale must have started in 1897 while an extract of kidney was once proven to be pressor. yet little was once performed with wisdom until eventually approximately 1929 whilst the connection of this kidney extract referred to as "renin" to high blood pressure was once pos· tulated. The pressor results have been, despite the fact that, not like so much of these obvious with sub· stances equivalent to epinephrine or vasopressin. Plasma used to be required for motion of renin and the energetic substance seemed to be protein. In 1939, it used to be proven that renin was once now not in itself a pressor substance yet really a proteolytic enzyme which produced a robust pressor substance performing on a substrate synthesized by way of the liver. Later it used to be famous that the 1st definable step after the formation of this peptide used to be cleaving of the decapeptide which had very little demonstrable task, with lack of amino acids to shape the octapeptide referred to as "angiotensin". inside a decade synthesis was once accomplished which made the substance to be had for world·wide study.

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II. Calculation of the percentage conversion of Ang. I to Ang. II within the wall of the vascular strip (Fig. 5) showed higher activity for pulmonary arteries (30 to 43 %) than for any other artery tested. Aortae of rats and carotid arteries of rabbits, cats and dogs exhibited much lower intramural conversion (5 to 10%) and celiac, renal, femoral and axillary arteries even less (0 and 4%). The high intramural conversion in strips of pulmonary artery is an interesting corollary of the high conversion in blood- or saline-perfused lungs.

SKEGGS, L. , LENTZ, K. , KAHN, J. , DORER, F. : Pseudorenin. A new angiotensin-forming enzyme. Circulat. Res. 25, 451 (1969). 16 L. T. : The Biological Production of Angiotensin SKEGGS, L. , LENTZ, K. , KAHN, J. : Studies on the preparation and properties of renin. Circulat. Res. 20-21 (Suppl. II), 91 (1967). SKEGGS, L. , LENTZ, K. , KAHN, J. : Kinetics oftha reaction of renin with nine synthetic peptide substrates. J. expo Med. 128,13 (1968). SKEGGS, L. , LENTZ, K. , KAHN, J. , DORER, F. : Multiple forms of human kidney renin.

222,186 (1969). , NAHMOD, V. , GOLDSTEIN, D. : Angiotensin and renin in rat and dog brain. J. expo Med. 133, 353 (1971). , BRECHT, H. : Evidence of renin release or production in splanchnic territory. ) 226, 551 (1970). , MINNICH, J. , BRECHT, H. forming enzyme in brain tissue. Science 173,64 (1972). angio. tensin system in the brain. In: Hypertension 1972. New York: Springer 1972. : La presence de cellules endocrines dans la paroi des arterioles du rein et leur comportement dans l'ischemie renale.

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